Opaleye Management Inc. Insider Trades

Entity

10% owner at Grace Therapeutics, Inc. and 3 other companies. 15 significant open-market trades reported on SEC Form 4 in the last 180 days.

On EDGAR, this filer has 232 Form 4 filings on record since 2015, the latest on Nov 5, 2026. Full history on sec.gov

$8.2M

Bought

$1.1M

Sold

14 / 1

Buys / Sells

Companies

GRCE10% owner
Grace Therapeutics, Inc.
3 buys, $419K
ACOG10% owner
Alpha Cognition Inc.
6 buys, $3.9M
SLGL10% owner
Sol-Gel Technologies Ltd.
5 buys, $3.9M · 2 alerts in our log
ETON10% owner
Eton Pharmaceuticals, Inc.
1 sell, $1.1M

Reported Trades

Open-market transactions only (code P and S), outside any 10b5-1 plan, dated by the day the filing reached EDGAR. Each row links to the filing.

Filed	Company	Trade	Value	Shares	Source
Oct 26, 2026	GRCE10% owner	buy	$159K	87,801	Form 4
Oct 26, 2026	ACOG10% owner	buy	$266K	32,090	Form 4
Oct 19, 2026	ACOG10% owner	buy	$309K	36,940	Form 4
Oct 16, 2026	GRCE10% owner	buy	$136K	71,065	Form 4
Oct 5, 2026	GRCE10% owner	buy	$124K	60,490	Form 4
Sep 28, 2026	ACOG10% owner	buy	$271K	31,763	Form 4
Sep 16, 2026	ACOG10% owner	buy	$1.1M	123,918	Form 4
Sep 14, 2026	SLGL10% owner	buy	$207K	3,124	Form 4
Sep 9, 2026	SLGL10% owner	buy	$687K	9,976	Form 4
Aug 31, 2026	SLGL10% owner	buy	$2.8M	40,330	Form 4
Aug 14, 2026	SLGL10% owner	buy	$68K	951	Form 4
Aug 4, 2026	ACOG10% owner	buy	$423K	52,900	Form 4
Jul 24, 2026	ACOG10% owner	buy	$1.6M	200,086	Form 4
Jul 16, 2026	ETON10% owner	sell	$1.1M	28,315	Form 4
Jul 15, 2026	SLGL10% owner	buy	$125K	1,695	Form 4

Other Insiders at These Companies

Everyone else who reported a significant open-market trade at the same companies in the last 180 days. Several insiders buying at once is cluster buying.

David KrempaChief Business Officer at ETON2 sells, $1.9MOct 6, 2026
Prashant KohliCEO at GRCE1 buy, $214KSep 10, 2026
Paul V. MaierDirector at ETON1 sell, $3.0MAug 28, 2026
Robert James WillsDirector at ACOG1 buy, $96KAug 24, 2026
Sean BrynjelsenPresident & CEO at ETON1 sell, $6.1MAug 20, 2026

How to Read This Page

These are the trades an insider chose to make with their own money, not grants, option exercises or tax withholding. A purchase is the stronger signal (why buys carry more information than sales), and an insider who buys is locked out of selling for six months by the short-swing rule. The window here is 180 days; the full filing history lives on EDGAR.

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